郦莉，杭州师范大学，衰老研究所，教授

教育经历：

2005/09 - 2011/02，美国密歇根大学，生物化学系，博士

2003/09 - 2005/07，中科院上海植物生理生态研究所，硕博连读

1999/09 - 2003/06，浙江大学，生命科学学院生物技术系，学士

联系方式：

电话: 0571-28865729   邮箱：lili@hznu.edu.cn

地址：杭师大科技园D615

科研与学术工作经历：

2013/08 - 至今，杭州师范大学，教授

2011/06 - 2013/01，美国Sanford-Burnham Medical Research Institute，博士后

2011/02 - 2011/05，美国加州大学圣地亚哥分校，药学系，博士后

主持或参加科研项目（课题）情况：

1、国家自然科学基金面上项目，81571375，PTEN－端粒互作调控卵巢衰老的机制研究，2016/01-2019/12，59万元，在研，主持

2、国家自然科学基金青年项目，81401144，PTEN－端粒互作调控细胞衰老的机制研究，2015/01-2017/12，23万元，已结题，主持

代表性研究成果和学术奖励情况:

1. Xinyan Ji, Lihua Song, Li Sheng , Anhui Gao, Yang Zhao, Shixun Han, Yuchao Zhang, Chu Zhu, Simeng Zhao, Zhe Wang, Bohan Xu, Li Li, Jia Li, Ninghua Tan* and Bin Zhao*. “Cyclopeptide RA-V Inhibits Organ Enlargement and Tumorigenesis Induced by YAP Activation”. Cancers (Basel). 2018 Nov 16;10(11).

2. Lu Deng , Lei Chen, Linlin Zhao, Yan Xu, Xiaoping Peng, Xinbo Wang, Lin Ding, Jiali Jin, Hongqi Teng, Yanming Wang, Weijuan Pan, Fei Yu, Lujian Liao, Li Li, Xin Ge and Ping Wang. “Ubiquitination of Rheb governs growth factor-induced mTORC1 activation”. Cell Research. 2019 Feb;29(2):136-150.

3. Huan Liu, Xiaoming Dai, Xiaolei Cao, Huan Yan, Xinyan Ji, Haitao Zhang, Shuying Shen, Yuan Si, Hailong Zhang, Jianfeng Chen, Li Li, Jonathan C Zhao, Jindan Yu, Xin-Hua Feng & Bin Zhao. “PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin β2 expression”. EMBO reports (2018) 19, e45180.

4. Chu Zhu, Xinyan Ji, Haitao Zhang, Qi Zhou, Xiaolei Cao, Mei Tang, Yuan Si, Huan Yan, Li Li, Tingbo Liang, Xin-Hua Feng and Bin Zhao.“Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway”. J Biol Chem (2018) 293(4):1178-1191.

5. Yuan Si, Xinyan Ji, Xiaolei Cao, Xiaoming Dai, Lingyi Xu, Hongxia Zhao, Xiaocan Guo, Huan Yan, Haitao Zhang, Chu Zhu, Qi Zhou, Mei Tang, Zongping Xia, Li Li, Yu-Sheng Cong, Sheng Ye, Tingbo Liang, Xin-Hua Feng and Bin Zhao. “Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1”. Cancer Res. 2017 Sep 15;77(18):4868-4880.

6. Xiaocan Guo, Yang Zhao, Huan Yan, Yingcheng Yang, Shuying Shen, Xiaoming Dai, Xinyan Ji, Fubo Ji, Xing-Guo Gong, Li Li, Xueli Bai, Xin-Hua Feng, Tingbo Liang, Junfang Ji, Lei Chen, Hongyang Wang, and Bin Zhao. “Single tumor-initiating cells evade immune clearance by recruiting type II macrophages.” Genes Dev. 2017 Feb 1;31(3):247-259.

7. Xiaoming Dai, Huan Liu, Shuying Shen, Xiaocan Guo, Huan Yan, Xinyan Ji, Li Li, Jun Huang, Xin-Hua Feng, Bin Zhao. “YAP activates the Hippo pathway in a negative feedback loop”. Cell Res. 2017 Aug; 27(8):1073.

8. Shuying Shen, Xiaocan Guo, Huan Yan,Yi Lu,Xinyan Ji, Li Li, Tingbo Liang, Dawang Zhou, Xin-Hua Feng, Jonathan C Zhao, Jindan Yu, Xing-Guo Gong, Lei Zhang, and Bin Zhao,“A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis.”. Cell Res. 2015 Sep; 25(9): 997–1012.

9. Qi Zhou, Li Li, Bin Zhao,* and Kun-Liang Guan*. “The hippo pathway in heart development, regeneration, and diseases.”.Circ Res. 2015 Apr 10;116 (8):1431-1447.