王丽辉，杭州师范大学，衰老研究所，讲师

教育经历：

2006/09-2009/06，中山大学，肿瘤防治中心，博士

2003/09-2006/06，浙江大学，生命科学学院，硕士

1999/09-2003/06，东北农业大学，生命科学学院，学士

联系方式：

电话: 0571-28861733   邮箱：wanglihui100@163.com

地址：杭州市余杭区文一西路1378号杭州师范大学科技园D座609

工作经历：

2012/01-至今，杭州师范大学，医学院衰老研究所，讲师

2009/07-2011/11，华南师范大学，生物光子学研究院，讲师

学术兼职：

2018/03-至今，浙江省生物物理学会会长

研究方向:

端粒DNA损伤与肺相关疾病

主持科研项目情况：

1. 国家自然科学基金面上项目：81871112，端粒蛋白稳态异常和肺组织过早衰老的调控机制，2019/1-2022/12, 56万元，主持。

2. 国家自然科学基金重大研究计划培育项目：91849124，肺泡干细胞稳态异常与肺早衰及纤维化的机制，2019/1-2021/12, 50万元，主持。

3. 国家自然科学基金青年项目：81000955，细胞周期激酶在细胞衰老及肿瘤转移中的作用及其机制，2011/01-2013/12，20万元，已结题，主持。

代表性论文:

(1) Lihui Wang*（共同通讯作者）, Xianhua Xu, Jun-Ping Liu*. Telomere damage response and low-grade inflammation. Book Title: Regulation of Inflammatory Signaling in Health and Disease. Adv Exp Med Biol, 2017, 1024: 213-224.

(2) Lucy Cassar, Craig Nicholls, Alex R. Pinto, Ruping Chen, Lihui Wang, He Li and Junping Liu*. TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence. Protein & Cell, 2017, 8(1): 39-54.

(3) Junping Liu*, Jianfeng Li, Yanhua Lu, Lihui Wang and Gang Chen. Impulse control disorder, lysosomal malfunction and ATP13A2 insufficiency in Parkinsonism. 2017, Clin Exp Pharmacol Physiol, 44(2): 172-179.

(4) Guo Li*, Huiqian Wang, Lihui Wang, Ruping Chen, Junping Liu*. Distinct pathway of ERK1/2 activation by hydroxyl-carboxylic acid receptor-1. Plos One, 2014, 9(3), e93041

(5) Craig Nicholls, Alexander Ruvantha Pinto, He Li, Ling Li, Lihui Wang, Richard Simpson, Junping Liu*. Glyceradehyde-3-phosphate dehydrogenase (GAPDH) induces cancer cell senescence by interacting with telomerase RNA component. Proc Natl Acad Sci U S A, 2012, 109(33), 13308-13313.

(6) Lihui Wang, Jin Xiang, Min Yan, Yan Zhang, Yan Zhao, Caifeng Yue, Jie Xu, Feimeng Zheng, Jinna Chen, Zhuang Kang, Tongsheng Chen, Da Xing, Quentin Liu*. The mitotic kinase Aurora-A induces mammary cell migration and breast cancer metastasis by activating the Cofilin-F-actin pathway. Cancer Research, 2010, 70(22), 9118-9128.

(7) Jie Xu, Xiangbo Wan, Xuefei Huang, K. C Allen Chan, Minghuang Hong, Lihui Wang, Zijie Long, Qing Liu, Min Yan, Y. M Dennis Lo, Yixin Zeng, Quentin Liu*. Serologic antienzyme rate of Epstein-Barr virus DNase-specific neutralizing antibody segregates TNM classification in nasopharyngeal carcinoma. J Clin Oncol, 2010, 28(35), 5202-5209. 

(8) Jine Yao, Min Yan, Zhong Guan, Chaobin Pan, Liangping Xia, Chuanxing Li, Lihui Wang, Zijie Long, Yan Zhao, MW Li, Feimeng Zheng, Jie Xu and Quentin Liu*. Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival. Mol Cancer, 2009, 8, 95.

(9) Lihui Wang, Min Yan, Dazhi Xu, Junxia Cao, Xiaofeng Zhu, Yixin Zeng, Quentin Liu*. Requirement of Aurora-A kinase in astral microtubule polymerization and spindle microtubule flux. Cell Cycle, 2008, 7(8), 1104-1111.

(10) Xuefei Huang, Saokai Luo, Jie Xu, Juan Li, Duorong Xu, Lihui Wang, Min Yan, Xianren Wang, Xiangbo Wan, Feimeng Zheng, Yixin Zeng and Quentin Liu*. Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia. Blood, 2007, 111(5), 2854-2865.

(11) Zhong Guan, Xianren Wang, Xiaofeng Zhu, Xuefei Huang, Jie Xu, Lihui Wang, Xiangbo Wan, Zijie Long, Jiannan Liu, Gongkan Feng, Wenlin Huang, Yixin Zeng, Fujin Chen and Quentin Liu*. Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Cancer Research, 2007, 67(21), 10436-10444.