王志国，杭州师范大学，衰老研究所，副研究员

教育经历：

2007年9月‒2010年7月，中国科学院西北高原生物研究所，天然药物化学，理学博士

2004年9月‒2007年7月，曲阜师范大学，物理化学

2000年9月‒2004年7月，曲阜师范大学，化学工程与工艺，工学学士

联系方式：

电话: 0571-28861733   邮箱：zhgwang@aliyun.com 

地址：杭州市文一西路1378号杭州师范大学科技园D座609室

工作经历：

2010年9月至今，杭州师范大学，医学院。2016年获评杭州市教育局系统优秀教师

学术兼职

2018年9月-至今，Clinical and Experimental Pharmacology and Physiology,Editor

2018年4月-至今，浙江省生物物理学会，秘书

研究方向:

1.G-四链体生物学；  2.蛋白质工程及酶催化机制

主持科研项目情况（按时间倒序排序）：

1. 端粒蛋白稳态异常和肺组织过早衰老的调控机制，国家自然科学基金面上项目 81871112，2019.1‒2022.12，科研骨干（2/6）；

2. 老年医学学科发展战略研究项目，国家自然科学基金应急管理项目 81842036，2019.1‒2019.12，科研骨干（2/2）；

3. 光合玫瑰菌3-羟基丙酸循环固碳途径的分子机制，国家自然科学基金面上项目 31870740，2019.1‒2022.12，科研骨干（3/7）；

4. hnRNP A2*对人类端粒 G-四链体的解折叠机制研究 LY18H250002，浙江省自然科学基金面上项目，2018.1‒2020.12，项目负责人（1/5）；

5. 人类醛酮还原酶对葡萄糖分子的催化机制研究 31100584，国家自然科学基金青年项目，2012.1‒2014.12，项目负责人（1/6）；

6. 溶酶体ATP酶ATP13A2在帕金森氏病运动及行为障碍中的作用机制 91649205，国家自然科学基金重大项目，2017.1‒2020.12，科研骨干（4/10）；

7. ATP13A2 调控锰离子依赖性-synuclein寡聚体形成作用的研究 81501204, 国家自然科学基金青年项目，2016.1‒2018.12，科研骨干（3/6）；

8. 端粒相关蛋白对人类重大疾病作用机制的研究 2012CB911200，国家重大科学研究计划（973计划）项目（课题四 2012CB911204），2012.1‒2016.10科研骨干兼项目秘书（5/24）；

9. 抗菌肽CMⅣ的修饰改造及抗绿脓杆菌的作用研究 LQ13C050001，浙江省自然科学基金青年项目，2014.1‒2016.12科研骨干（2/6）；

10. miR-17-92基因簇在细胞衰老过程中的转录调控机制 31201038，国家自然科学基金青年项目，2013.1‒2015.12科研骨干（2/6）。

代表性论文:

1. Ming Sang; Chen Xu; Zhiheng Wei; Xiaolong Wu; Yuxing Guo; Jianfeng Li; Zhiguo Wang; Jiaxin Zhang*. Cloning and high-level SUMO-mediated fusion expression of a serine protease inhibitor from Hyphantria cunea Drury that exhibits activity against papain. Protein Expres. Purif. 2019, 158, 36-43.

2. Jun Liu*; Lihui Wang; Zhiguo Wang; Jun-Ping Liu*. Roles of Telomere Biology in Cell Senescence, Replicative and Chronological Ageing. Cells 2019, 8(1), 54-63. DOI: 10.3390/cells8010054.

3. Xueli, Cheng; Feng, Li; Yanyun Zhao; Zhiguo Wang; Chang-An Wang. Activation and recyclization of a benzocyclobutenone derivative catalyzed by a chiral Rh(I) complex based on DFT investigations. Chem. Pap. 2018, DOI: 10.1007/s11696-018-0641-1.

4. Zhiguo, Wang; Jianfeng, Li; Jun-Ping, Liu*. Effects of Cation Charges on the Binding of Stabilizers with Human Telomere and TERRA G-quadruplexes. J. Biomol. Struct. Dyn. 2018, DOI: 10.1080/07391102.2018.1471416.

5. Jinhu, Wang; Zhiguo, Wang*; Baoping, Ling; Hongqing, Yin; Xian-Man, Zhang; Xuejing, Liu. QM/MM Study of the dephosphorylation mechanism of adenosine 5’-(b,g-Imido)triphosphate catalyzed by sulfolobus tokodaii hexokinase. ChemistrySelect 2018, 3, 1674-1681.

6. Xiaoling, Xu; Huihao, Zhou; Quansheng, Zhou; Fei, Hong; My-Nuong Vo; Wanqiang, Niu; Zhiguo, Wang; Xiaolin, Xiong; Kanaha, Nakamura; Paul, Schimmel; Xiang-Lei, Yang*. An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function. RNA Biol. 2017, DOI: 10.1080/15476286.2017.1377868.

7. Zhiguo, Wang; Shuo, Zhou; Shuangling, Zhang; Sa, Zhang; Fangmeng, Zhu; Xiaolu, Jin; Zhenming, Chen*; Xiaoling, Xu*. Semi-rational engineering of a thermostable aldo–keto reductase from Thermotoga maritima for synthesis of enantiopure ethyl-2-hydroxy-4-phenylbutyrate (EHPB). Sci. Rep-UK. 2017, DOI:10.1038/s41598-017-03947-8.

8. Jinhu, Wang*; Zhiguo, Wang*; Baoping, Ling; Nan, Cao; Wen, Wang. Identification of a potential proton donor to the linking oxygen atom in a three-metal ion assisted catalysis pathway catalyzed by Fructose-1,6- bisphosphatase. J. Mol. Graph. Model. 2017, 73, 191-199.

9. Zhiguo, Wang*; Jun-Ping, Liu. Effects of the cental potassium ions on the G-quadruplex and stabilizer binding. J. Mol. Graph. Model. 2017, 72, 168-177.

10. Jianfeng, Li*; Jiaxin, Zhang; Zhiguo, Wang; Yingjia, Yao; Xu, Han; Youlong, Zhao; Junping Liu*; Shuangquan, Zhang*. Identification of a cyclodextrin inclusion complex of antimicrobial peptide CM4 and its antimicrobial activity. Food Chem. 2017, 221, 296-301.

11. Mengyan, He; Shuo, Zhou; Maolin, Cui; Xiaolu, Jin; Dunyue, Lai; Shuangling, Zhang; Zhiguo, Wang*; Zhenming, Chen*. Efficient preparation of (S)-N-Boc-3-Hydroxylpiperidine through bioreduction by a thermostable aldo-keto reductase. Appl. Biochem. Biotechnol. 2017, 181, 1304-1313.

12. Baoping, Ling*; Yuxia, Liu; Xiaoping, Li; Zhiguo, Wang; Siwei, Bi*. Identification of the active site of human mitochondrial malonyl-coenzyme a decarboxylase: A combined computational study. Proteins. 2016, 84, 792-802.

13. Zhiguo, Wang*; Ruping, Chen; Ling, Hou; Jianfeng, Li; Jun-Ping, Liu*. Molecular dynamics and principal components of potassium binding with human telomeric intra-molecular G-quadruplex. Protein Cell. 2015, 6, 423-433. (Cover story)

14. Zhiguo, Wang*; Jun-Ping, Liu*. Characterization of potassium binding with human telomeres. Clin. Exp. Pharmacol. P. 2015, 42, 902-909.

15. Jianfeng, Li*; Jian, Li; Zhiguo, Wang; Hongzhen, Liu; Youlong, Zhao; Jinxi, Zhang; Shuangquan, Zhang*; Junping Liu*. Identification of interferon-g- inducible-lysosomal thiol reductase (GILT) gene in goldfish (Carassius auratus) and its immune response to LPS challenge. Fish Shellfish Immunol. 2015, 42, 465-472.

16. Zhenming, Chen; Yuanhui, Ma; Mengyan, He; Hongyang, Ren; Shuo, Zhou; Dunyue, Lai; Zhiguo, Wang*; Linshu, Jiang*. Semi-rational directed evolution of monoamine oxidase for kinetic resolution of rac-maxiletine. Appl. Biochem. Biotechnol. 2015, 176, 2267-2278.

17. Xuejun, Chen; Yuanhui, Ma; Jianhua, Shao; Dunyue, Lai; Zhiguo, Wang*; Zhenming, Chen*. Increasing activity of a monoamine oxidase by random mutation. Chin. J. Biotech. 2014, 30, 109-118.

18. Baoping, Ling*; Min, Sun; Siwei, Bi; Zhihong, Jing; Zhiguo, Wang. Molecular dynamics simulations of isoleucine-release pathway in GAF domain of N-CodY from Bacillus Subtilis. J. Mol. Graph. Model. 2013, 44, 232-240.

19. Rui, Zhang; Zhiguo, Wang; Baoping, Ling; Yongjun, Liu*; Chengbu, Liu. Docking and molecular dynamics studies on the interaction of four imidazoline derivatives with potassium ion channel (Kir6.2). Mol. Simulat. 2010, 36, 166-174.

20. Baoping, Ling; Rui, Zhang; Zhiguo, Wang; Yongjun, Liu*; Chengbu, Liu. Study on the interactions of Smacmimetics with XIAP-BIR3 domain by docking and molecular dynamics simulations. J. Theor. Comput. Chem. 2010, 9, 797-812.

21. Baoping, Ling; Rui, Zhang; Zhiguo, Wang; Lihua, Dong; Yongjun, Liu*, Changqiao, Zhang; Chengbu, Liu. Theoretical studies on the interaction of guanine riboswitch with guanine and its closest analogues. Mol. Simulat 2010, 36, 929-938.

22. Zhiguo, Wang; Baoping, Ling; Rui, Zhang; Yourui, Suo; Yongjun, Liu*; Zhangyu, Yu; Chengbu, Liu. Docking and molecular dynamics studies toward the binding of new natural phenolic marine inhibitors and aldose reductase. J. Mol. Graph. Model. 2009, 28, 162-169.

23. Baoping, Ling; Zhiguo, Wang; Rui, Zhang; Xianghua, Meng; Yongjun, Liu*; Changqiao, Zhang; Chengbu, Liu. Theoretical studies on the interaction of modified pyrimidines and purines with purine riboswitch. J. Mol. Graph. Model. 2009, 28, 37-45.

24. Rui, Zhang; Baoping, Ling; Xianghua, Meng; Zhiguo, Wang; Changqiao Zhang; Yongjun, Liu*; Chengbu, Liu. Docking studies on the interaction of imidazolines and potassium ion channel–Kir6.2. Chem. J. Chinese U. 2009, 30, 2268-2273.

25. Zhiguo, Wang; Baoping, Ling; Rui, Zhang; Yongjun, Liu*. Docking and molecular dynamics study on the inhibitory activity of coumarins on aldose reductase. J. Phys. Chem. B 2008, 112, 10033-10040.

26. Zhiguo, Wang; Honglun, Wang; Yongjun, Liu*; Yourui, Suo. Addition reactions of nitrones on the reconstructed C(100)-2×1 surfaces. J. Mol. Struct. (THEOCHEM) 2008, 850, 72-78.

27. Yongli, Sheng; Menghua, Li; Zhiguo, Wang; Yongjun, Liu*. Theoretical investigation on the adsorption of Ag+ and hydrated Ag+ on clean Si(111) surface. Chinese J. Struc. Chem. 2008, 27, 326-334.

28. Yongjun, Liu*; Zhiguo, Wang. Addition reaction of nitrones on the reconstructed Si(100)-2×1 surface. J. Phys. Chem. C 2007, 111, 4673-4677.

   29. Yongjun, Liu*; Zhiguo, Wang. Theoretical study on adsorption of Na+ and Na+(H2O)n (n=1-6) on a clean Si(111) surface. J. Phys. Chem. C 2007, 111, 3427-3432.